When using eDOT the major concern for the clinical trial is the lost opportunity of building rapport with the patient to determine if they are “intentionally” or “unintentionally” non-adherent. Some patients thrive on personal contact and the opportunity for tailored counseling.
Intentional medication non-adherence is an active decision from the patient to take their medication as prescribed. This is a process in which a patient makes a rational decision based on the benefits of medication adherence compared to risks of medication non-adherence.
Unintentional medication non-adherence is a passive process in which the patient does not adhere to how the medication is prescribed because they forget, don’t understand, or because of poor health literacy.
Dr Donald Morisky.