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The difference between the MMAS-4 and the MMAS-8 is that the MMAS-4 has very low reliability (Cronbach's alpha is only .68) compared to the .83 for the MMAS-8. The MMAS-8 also has been able to identify many more long-term outcomes compared with the MMAS-4.
Specifically, there are many more independent variables such as beliefs in medication-taking behavior as well as strong associations with knowledge of the medical regimen and positive attitudes regarding medication taking behavior. Long-term outcomes include a very strong correlation of the MMAS-8 with the proportion in control of their health condition, reduction in 30-day appointment-keeping, quality of life, morbidity and mortality. Journal Articles regarding determinants of nonadherence Retrospective Cohort Study of Medication Adherence and Risk for 30-day Hospital Readmission in a Medicare Cost Plan Barriers to Determinants of Medication Adherence in Hypertension Management: Perspective of Cohort Study of Medication Adherence Among Older Adults Predictive Validity of a Medication Adherence Measure in an Outpatient Setting Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes
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AuthorMarty Morisky, MS CSP CSHM Archives
April 2026
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