Limitations of eDOT and why Clinical Trials prefer to use the Morisky Method.

When using eDOT the major concern for the clinical trial is the lost opportunity of building rapport with the patient to determine if they are “intentionally” or “unintentionally” non-adherent. Some patients thrive on personal contact and the opportunity for tailored counseling.

​Intentional medication non-adherence is an active decision from the patient to take their medication as prescribed. This is a process in which a patient makes a rational decision based on the benefits of medication adherence compared to risks of medication non-adherence.

​Unintentional medication non-adherence is a passive process in which the patient does not adhere to how the medication is prescribed because they forget, don’t understand, or because of poor health literacy.